Methyl 7-aza-2-oxindole-5-carboxylate
Methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate
CAS: 1190317-75-9
Molecular Formula: C9H8N2O3
Methyl 7-aza-2-oxindole-5-carboxylate - Names and Identifiers
Methyl 7-aza-2-oxindole-5-carboxylate - Physico-chemical Properties
| Molecular Formula | C9H8N2O3 |
| Molar Mass | 192.17 |
| Density | 1.351±0.06 g/cm3(Predicted) |
| Boling Point | 427.8±45.0 °C(Predicted) |
| pKa | 12.07±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD25541767 |
Methyl 7-aza-2-oxindole-5-carboxylate - Introduction
Methyl 2-keto-1-((2-(trimethylsilyl) ethoxy) methyl) 2,3-dihydro-5-carboxylate-7-azaindole is an organic compound whose chemical formula is C20H29NO5Si.
Nature:
The compound was a white crystalline solid. It is insoluble in water, but soluble in organic solvents such as ethanol, diethyl ether and dichloromethane.
Use:
The compound has important application value in the field of organic synthesis. It can be used as pyrrolidine deprotection reagent, and in the synthesis of compounds with the activity of nitrogen heterocyclic structure.
Preparation Method:
The specific synthesis method can be carried out by a multi-step reaction. First, a carboxylic acid ester is obtained by reacting trimethylsilanylethiol with a carboxylic acid by an appropriate organic synthesis method. Subsequently, the carboxylic acid ester is reacted with indoline, and condensation, ketonization and ethoxy protection are carried out.
Safety Information:
Due to the lack of specific safety data, the specific safety of this compound still needs further evaluation. Appropriate laboratory safety practices, such as wearing protective gloves, safety glasses and goggles, should be used during handling and use. This reduces the risk of exposure and ensures personal safety.
Nature:
The compound was a white crystalline solid. It is insoluble in water, but soluble in organic solvents such as ethanol, diethyl ether and dichloromethane.
Use:
The compound has important application value in the field of organic synthesis. It can be used as pyrrolidine deprotection reagent, and in the synthesis of compounds with the activity of nitrogen heterocyclic structure.
Preparation Method:
The specific synthesis method can be carried out by a multi-step reaction. First, a carboxylic acid ester is obtained by reacting trimethylsilanylethiol with a carboxylic acid by an appropriate organic synthesis method. Subsequently, the carboxylic acid ester is reacted with indoline, and condensation, ketonization and ethoxy protection are carried out.
Safety Information:
Due to the lack of specific safety data, the specific safety of this compound still needs further evaluation. Appropriate laboratory safety practices, such as wearing protective gloves, safety glasses and goggles, should be used during handling and use. This reduces the risk of exposure and ensures personal safety.
Last Update：2024-04-10 22:29:15
